Vimeo, Twitter, Googlemaps Permit embedded content and cookies from third party providers. Both cells form a ring-shaped structure made of different proteins at the point of contact between the cells — termed immunological synapse — over which they can exchange information. Her ability to combine new technical approaches with leadership of international consortia at unprecedented size, has put her at the forefront of human genetics today. This cell type is responsible for classifying the presented parts as dangerous or harmless and, if necessary, initiating a response against them. At the end of this process the T-cell is either activated or remains inactive. This setting enables the full use of our web services e. Anastasios Siokis, Philippe A. Third party content and cookies e. Print Send per email Share.
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Different immune cells are therefore constantly in search of foreign molecules indicating the presence of any pathogen which needs to be destroyed.
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These tasks are shared among different cell types: Eleftheria Zeggini has published hundreds of publications, frequently as lead author in top journals such as Nature, Nature Genetics and Science. There you may also change your settings later. HZI researchers have investigated the formation of immunological synapses over which immune cells exchange information The immune system protects the human body against pathogens thus keeping it healthy.
Our extensive epidemiology program that includes leadership of the German National Cohort NAKO along with our ambitious new initiatives in applied artificial intelligence and digital health will now offer Professor Zeggini synergistic opportunities to accelerate her research. Researchers of the Helmholtz Centre for Infection Research HZI and the Braunschweig Integrated Centre of Systems Biology BRICSin collaboration with researchers at the University of Oxford UKhave now simulated the dynamic arrangement of these components using computer models and have subsequently been able to make inferences on the mechanisms involved in the formation of synapses.
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Dustin to simulate the formation of synapses using computer models. Further Information Please find more details about the research of Eleftheria Zeggini and her team on the website of the Institute of Translational Genomics. Before moving to the Sanger Institute, Eleftheria Zeggini worked at the Universities of Manchester and Oxford, where, among other things, she made breakthrough discoveries in juvenile arthritis, rheumatic diseases and type 2 diabetes.
T-cells red and B-cells blue form immunological synapses at their contact point green. At the end of this process the T-cell is either activated or remains inactive. Involved Groups Systems Immunology.
|Dustin to simulate the formation of synapses using computer models.
This cell type is responsible for classifying the presented parts as dangerous or harmless and, if necessary, initiating a response against them. If all the components of the synapse are correctly positioned, activation of the immune cell will result.
Functions Print Share on facebook Share on twitter. They organise themselves in small clusters which are transported by actin in the direction of the centre of the synapse.
Both cells form a characteristic ring-shaped structure at their contact point, the immunological synapse, through which they exchange information. The large adhesion molecules accumulate around them in an outer ring.